XPC - XPC complex subunit, DNA damage recognition and repair factor Gene
基因
蛋白
疾病
相关产品
直系同源
中文名称：XPC 复合亚基、DNA 损伤识别和修复因子
种属: Homo sapiens
同用名: XP3; RAD4; XPCC; p125
基因 ID: 7508
|
基因类型: protein coding
关于 XPC
Cytogenetic location: 3p25.1
Genomic coordinates (GRCh38): 3:14,145,147-14,178,601 (from NCBI)
This gene has 7 transcripts (splice variants), 197 orthologues and is associated with 86 phenotypes. Ubiquitous expression in ovary (RPKM 17.1), kidney (RPKM 15.8) and 25 other tissues.
功能概要
该基因编码的蛋白质是 XPC 复合体的关键组成部分，在全基因组核苷酸切除修复 (NER) 的早期步骤中发挥重要作用。编码的蛋白质对于损伤感知和 DNA 结合很重要，并且显示出对单链 DNA 的偏好。该基因或其他一些 NER 成分的突变可导致着色性干皮病，这是一种罕见的常染色体隐性遗传病，其特征是对阳光的敏感性增加，并在早期发展为癌症。已发现该基因的可变剪接转录物变体。[RefSeq 提供，2017 年 8 月]
The protein encoded by this gene is a key component of the XPC complex, which plays an important role in the early steps of global genome nucleotide excision repair (NER). The encoded protein is important for damage sensing and DNA binding, and shows a preference for single-stranded DNA. Mutations in this gene or some Other NER components can result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2017]
XPC 基因产物(5)
mRNA
Protein
Name
NM_001354726.2
NP_001341655.1
DNA repair protein complementing XP-C cells isoform 3
NM_001354727.2
NP_001341656.1
DNA repair protein complementing XP-C cells isoform 4
NM_001354729.2
NP_001341658.1
DNA repair protein complementing XP-C cells isoform 5
NM_001354730.2
NP_001341659.1
DNA repair protein complementing XP-C cells isoform 6
NM_004628.5
NP_004619.3
DNA repair protein complementing XP-C cells isoform 1
基因本体论
分子功能
生物过程
细胞组分
分子功能 GO 注释
逻辑证据
参考文献
来源
enables DNA damage sensor activity
IDA
IDA: 通过直接分析推断
10873465
GOA
enables damaged DNA binding
IDA
IDA: 通过直接分析推断
12509299
GOA
enables protein binding
IPI
IPI: 通过物理相互作用推断
10488153
GOA
enables protein-containing complex binding
IDA
IDA: 通过直接分析推断
11259578
GOA
enables single-stranded DNA binding
IDA
IDA: 通过直接分析推断
12509299
GOA
enables transcription coactivator activity
IDA
IDA: 通过直接分析推断
29973595
GOA
生物过程 GO 注释
逻辑证据
参考文献
来源
involved in UV-damage excision repair
IDA
IDA: 通过直接分析推断
8077226
GOA
involved in nucleotide-excision repair
IDA
IDA: 通过直接分析推断
8168482
GOA
involved in positive regulation of DNA-templated transcription
IDA
IDA: 通过直接分析推断
29973595
GOA
involved in regulation of mitotic cell cycle phase transition
IMP
IMP: 通过突变表型推断
17088560
GOA
细胞组分 GO 注释
逻辑证据
参考文献
来源
part of XPC complex
IDA
IDA: 通过直接分析推断
11279143
GOA
located in cytoplasm
IDA
IDA: 通过直接分析推断
18682493
GOA
part of nucleotide-excision repair complex
IDA
IDA: 通过直接分析推断
11259578
GOA
located in nucleus
IDA
IDA: 通过直接分析推断
18682493
GOA
EXP：通过实验结果推断
IDA：通过直接分析推断
IPI：通过物理相互作用推断
IMP：通过突变表型推断
IGI：通过遗传相互作用推断
IEP：通过表达模式推断
XPC 蛋白结构
Rad4
Rad4: Rad4 transglutaminase-like domain (501 - 625)
BHD_1
BHD_1: Rad4 beta-hairpin domain 1 (631 - 682)
BHD_2
BHD_2: Rad4 beta-hairpin domain 2 (684 - 744)
BHD_3
BHD_3: Rad4 beta-hairpin domain 3 (751 - 825)
0
200
400
600
800
940 a.a.
蛋白主名
其他名称
DNA repair protein complementing XP-C cells
mutant xeroderma pigmentosum group C
XPC 蛋白互作信息
分类
蛋白名称
蛋白编号
互作蛋白
互作蛋白种属
互作蛋白编号
实验方法
参考文献
种属内
XPC
Q01831
ERCC3
Homo sapiens
P19447
Anti Tag CoIP
34591642
种属内
XPC
Q01831
ERCC3
Homo sapiens
P19447
Pull Down
10734143
种属内
XPC
Q01831
CETN2
Homo sapiens
P41208
Anti Tag CoIP
34591612
种属内
XPC
Q01831
CETN2
Homo sapiens
P41208
Anti Tag CoIP
34591642
种属内
XPC
Q01831
CETN2
Homo sapiens
P41208
Pull Down
21962512
种属内
XPC
Q01831
CETN2
Homo sapiens
P41208
Anti Tag CoIP
33961781
种属内
XPC
Q01831
CETN2
Homo sapiens
P41208
Anti Tag CoIP
28514442
种属内
XPC
Q01831
PSMC5
Homo sapiens
P62195
Pull Down
17693435
种属内
XPC
Q01831
GTF2H1
Homo sapiens
P32780
Anti Tag CoIP
34591642
种属内
XPC
Q01831
GTF2H1
Homo sapiens
P32780
Pull Down
10734143
种属内
XPC
Q01831
RAD23B
Homo sapiens
P54727
Anti Tag CoIP
34591612
种属内
XPC
Q01831
RAD23B
Homo sapiens
P54727
Anti Tag CoIP
33961781
种属内
XPC
Q01831
RAD23B
Homo sapiens
P54727
Anti Tag CoIP
34591642
种属内
XPC
Q01831
RAD23B
Homo sapiens
P54727
Affinity Chrom
21962512
种属内
XPC
Q01831
RAD23B
Homo sapiens
P54727
Y2H
10488153
种属间
XPC
Q01831
kr2_ebvb9
Epstein-Barr virus
P13288
Pull Down
18024891
种属间
XPC
Q01831
kr2_ebvb9
Epstein-Barr virus
P13288
Anti Bait CoIP
18024891
种属间
XPC
Q01831
kr2_ebvb9
Epstein-Barr virus
P13288
Anti Tag CoIP
18024891
种属间
XPC
Q01831
kr2_ebvb9
Epstein-Barr virus
P13288
IF
18024891
种属间: 跨种属相互作用
种属内: 同种属相互作用
XPC 抗体
目录号
产品名
应用
反应物种
HY-P84461
XPC Antibody (YA4158)
WB, IHC-P, ICC/IF, FC, ELISA
Human
关联疾病
疾病名称
别名
Xeroderma Pigmentosum, Complementation Group C
Xeroderma Pigmentosum, Group C
XPC
Xpcc
Xeroderma Pigmentosum Iii
Xp3
Xeroderma Pigmentosum Group C
Xp Group C
Xp, Group C
Xeroderma Pigmentosum, Type 3
Xeroderma Pigmentosum Complementation Group C
XP-C
Xeroderma Pigmentosum, Variant Type
Xeroderma Pigmentosum
XPV
Xeroderma Pigmentosum Variant Type
Xeroderma Pigmentosum With Normal Dna Repair Rates
Photosensitivity With Defective Dna Synthesis
Xp
De Sanctis-Cacchione Syndrome
Desanctis-Cacchione Syndrome
Xeroderma Pigmentosa
Xerodermic Idiocy
Xeroderma Pigmentosum Variant
Xp - [Xeroderma Pigmentosum]
Atrophoderma Pigmentosum
Xeroderma Pigmentosum, Complementation Group A
Xeroderma Pigmentosum Group A
Xp1
Xeroderma Pigmentosum, Group A
XPA
Xeroderma Pigmentosum I
Xeroderma Pigmentosum Complementation Group A
Xp Group A
Xp, Group A
Xeroderma Pigmentosum 1
Xeroderma Pigmentosum, Type 1
XP-A
Cockayne Syndrome
Cockayne'S Syndrome
Dwarfism-Retinal Atrophy-Deafness Syndrome
Neill-Dingwall Syndrome
Progeria-Like Syndrome
Progeroid Nanism
Cs
Xeroderma Pigmentosum, Complementation Group E
Xeroderma Pigmentosum V
Xp5
Xeroderma Pigmentosum, Group E, Ddb-Negative Subtype
Xpe
Xp, Group E
Xeroderma Pigmentosum, Type 5
Xeroderma Pigmentosum Complementation Group E
XP-E
Xp Group E
Trichothiodystrophy
Ttd
Amish Brittle Hair Syndrome
Bids Syndrome
Brittle Hair-Intellectual Impairment-Decreased Fertility-Short Stature Syndrome
Ibids
Pibids
Trichothiodystrophy Syndromes
Li-Fraumeni Syndrome
Sarcoma Family Syndrome Of Li And Fraumeni
Sbla Syndrome
LFS
Li-Fraumeni Familiar Cancer Susceptibility Syndrome
Sarcoma, Breast, Leukaemia And Adrenal Gland Syndrome
Lfs1
Li Fraumeni Syndrome
Sarcoma, Breast, Leukemia, And Adrenal Gland Syndrome
Lfl
Sbla Syndrome Li-Fraumeni-Like Syndrome
Li-Fraumeni Syndrome 1
Prostate Calculus
Calculus Of Prostate
Prostatic Lithiasis
Stone Of Prostate
Prostatic Stone
Prostate Calculi
Prostatolithiasis
Skin Carcinoma
Skin Cancer
Carcinoma Of Skin
Ca - Skin Cancer
Cancer Of Skin
Malignant Neoplasm Of Skin
Melanoma And Non-Melanoma Skin Cancer
Skin Cancers
Cancer, Skin
Xeroderma Pigmentosum, Complementation Group G
Xeroderma Pigmentosum, Group G
Xeroderma Pigmentosum Vii
Xp7
XPG
Xeroderma Pigmentosum Group G
Xp Group G
Xp, Group G
Xpgc
Xeroderma Pigmentosum, Group G/Cockayne Syndrome
Xeroderma Pigmentosum, Type 7
Xeroderma Pigmentosum Complementation Group G
XP-G
Xp-G/Cs
Xeroderma Pigmentosum Group G/Cockayne Syndrome
Uv-Sensitive Syndrome
Uvss
Uv Sensitive Syndrome
Ultraviolet Sensitive Syndrome
Cockayne Syndrome A
Cockayne Syndrome Type 1
Cockayne Syndrome, Type A
Cockayne Syndrome Type I
CSA
Cockayne Syndrome Classic Form
Cockayne Syndrome Classical
Cockayne Syndrome Type A
Ckn1
Huntington Disease
Huntington'S Disease
Huntington Chorea
Huntington'S Chorea
HD
Huntington Chronic Progressive Hereditary Chorea
Juvenile Huntington Disease
Chronic Progressive Chorea
Chronic Progressive Hereditary Chorea
Hc - [Huntington Chorea]
Hereditary Chorea
Progressive Hereditary Chorea
疾病名称
别名
Waldenstroem'S Macroglobulinemia
Waldenstroem'S Macroglobulinemia
Waldenstroem'S Macroglobulinemia
Macroglobulinemia Of Waldenstrom
Lymphoplasmacytic Lymphoma With Igm Gammopathy
Lymphoplasmacytic Lymphoma
Waldenstroem'S Macroglobulinemia
Waldenstroem'S Macroglobulinemia
Macroglobulinemia Of Waldenstrom
Lymphoplasmacytic Lymphoma With Igm Gammopathy
Lymphoplasmacytic Lymphoma
相关产品
Pre-clinical Phase
生物活性分子
(6)
Cat. No.
产品名
作用方式
纯度
是否罕见病
HY-157784
XPC-7724
Inhibitor
98.97%
否
HY-157786
XPC-5462
Inhibitor
98.25%
否
HY-128772
XPC-6444
Inhibitor
98.93
否
HY-RS15885
XPC Human Pre-designed siRNA Set A
Pre-designed Set
/
否
HY-RS20245
Xpc Mouse Pre-designed siRNA Set A
Pre-designed Set
/
否
HY-RS26753
Xpc Rat Pre-designed siRNA Set A
Pre-designed Set
/
否
直系同源
种属
基因名
来源
基因 ID
Felis catus
XPC
VGNC
VGNC:67109
Canis familiaris
XPC
VGNC
VGNC:48456
Mus musculus
XPC
MGD
MGI:103557
Macaca mulatta
XPC
VGNC
VGNC:78809
Rattus norvegicus
XPC
RGD
RGD:1305760
Bos taurus
XPC
VGNC
VGNC:36993
Compound Screening Libraries
实体化合物库
Virtual Screening
虚拟筛选
Customize Your Library
定制专属化合物库
Drug Screening Service
药物筛选服务